GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease.

Details

Serval ID
serval:BIB_BCB65D4BAEEF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease.
Journal
Journal of clinical medicine
Author(s)
Duarte Azevedo M., Sander S., Tenenbaum L.
ISSN
2077-0383 (Print)
ISSN-L
2077-0383
Publication state
Published
Issued date
07/02/2020
Peer-reviewed
Oui
Volume
9
Number
2
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with the GDNF family receptor α1 (GFRα1), which is mainly expressed by neurons and can act in cis as a membrane-bound factor or in trans as a soluble factor. The GDNF/GFRα1 complex signals through interactions with the "rearranged during transfection" (RET) receptor or via the neural cell adhesion molecule (NCAM) with a lower affinity. GDNF can also signal independently from GFRα1 by interacting with syndecan-3. RET, which is expressed by neurons involved in several pathways (nigro-striatal dopaminergic neurons, motor neurons, enteric neurons, sensory neurons, etc.), could be the main determinant of the specificity of GDNF's pro-survival effect. In an injured brain, de novo expression of GDNF occurs in glial cells. Neuroinflammation has been reported to induce GDNF expression in activated astrocytes and microglia, infiltrating macrophages, nestin-positive reactive astrocytes, and neuron/glia (NG2) positive microglia-like cells. This disease-related GDNF overexpression can be either beneficial or detrimental depending on the localization in the brain and the level and duration of glial cell activation. Some reports also describe the upregulation of RET and GFRα1 in glial cells, suggesting that GDNF could modulate neuroinflammation.
Keywords
GDNF family receptor alpha 1, Parkinson’s disease, astrocyte, gene therapy, glial-cell-line-derived neurotrophic factor, microglia, neuroinflammation, rearranged during transfection
Pubmed
Open Access
Yes
Create date
14/02/2020 17:34
Last modification date
26/02/2020 7:26
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