Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice

Details

Serval ID
serval:BIB_BC92CE4B6A2F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice
Journal
Neuron
Author(s)
Knott  G. W., Quairiaux  C., Genoud  C., Welker  E.
ISSN
0896-6273 (Print)
Publication state
Published
Issued date
04/2002
Volume
34
Number
2
Pages
265-73
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr 11
Abstract
During development, alterations in sensory experience modify the structure of cortical neurons, particularly at the level of the dendritic spine. Are similar adaptations involved in plasticity of the adult cortex? Here we show that a 24 hr period of single whisker stimulation in freely moving adult mice increases, by 36%, the total synaptic density in the corresponding cortical barrel. This is due to an increase in both excitatory and inhibitory synapses found on spines. Four days after stimulation, the inhibitory inputs to the spines remain despite total synaptic density returning to pre-stimulation levels. Functional analysis of layer IV cells demonstrated altered response properties, immediately after stimulation, as well as four days later. These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex.
Keywords
Animals Dendrites/*physiology/ultrastructure Female Mice Mice, Inbred ICR Microscopy, Electron Neuronal Plasticity/physiology Physical Stimulation Somatosensory Cortex/*physiology/ultrastructure Synapses/*physiology/ultrastructure Vibrissae/*physiology gamma-Aminobutyric Acid/*physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:40
Last modification date
14/01/2021 9:35
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