Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_BC418C20751B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Imaging angiogenesis in atherosclerosis in large arteries with 68Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.
Journal
EJNMMI research
Author(s)
Dietz M., Kamani C.H., Deshayes E., Dunet V., Mitsakis P., Coukos G., Nicod Lalonde M., Schaefer N., Prior J.O.
ISSN
2191-219X (Print)
ISSN-L
2191-219X
Publication state
Published
Issued date
14/08/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
71
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of <sup>68</sup> Ga-NODAGA-RGD, a specific α <sub>v</sub> β <sub>3</sub> integrin ligand for PET.
The data of 44 patients who underwent <sup>68</sup> Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed semi-quantitatively by blood-pool-corrected target-to-background ratios. Tracer uptake was compared with clinically documented atherosclerotic cardiovascular disease, cardiovascular risk factors and calcified plaque burden. Data were compared using the Mann-Whitney U test, Pearson correlation and Spearman correlation.
<sup>68</sup> Ga-NODAGA-RGD arterial uptake was significantly higher in patients with previous clinically documented atherosclerotic cardiovascular disease (mean TBR 2.44 [2.03-2.55] vs. 1.81 [1.56-1.96], p = 0.001) and showed a significant correlation with prior cardiovascular or cerebrovascular event (r = 0.33, p = 0.027), BMI (ρ = 0.38, p = 0.01), plaque burden (ρ = 0.31, p = 0.04) and hypercholesterolemia (r = 0.31, p = 0.04).
<sup>68</sup> Ga-NODAGA-RGD holds promise as a non-invasive marker of disease activity in atherosclerosis, providing information about intraplaque angiogenesis.
Keywords
68Ga-NODAGA-RGD, Angiogenesis, Atherosclerosis, PET/CT
Pubmed
Web of science
Open Access
Yes
Create date
03/09/2021 18:31
Last modification date
04/03/2022 7:33
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