Diagnostic Performance of <sup>18</sup>F-FDG PET/CT in Native Valve Endocarditis: Systematic Review and Bivariate Meta-Analysis.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_BC3B9C2D5E75
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic Performance of <sup>18</sup>F-FDG PET/CT in Native Valve Endocarditis: Systematic Review and Bivariate Meta-Analysis.
Journal
Diagnostics
Author(s)
Kamani C.H., Allenbach G., Jreige M., Pavon A.G., Meyer M., Testart N., Firsova M., Fernandes Vieira V., Boughdad S., Nicod Lalonde M., Schaefer N., Guery B., Monney P., Prior J.O., Treglia G.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
25/09/2020
Peer-reviewed
Oui
Volume
10
Number
10
Pages
754
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Infectious endocarditis is a life-threatening disease, requiring prompt and accurate diagnosis. The aim of this article is to perform a systematic review and meta-analysis of the literature to estimate the performance of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ( <sup>18</sup> F-FDG PET/CT) for the diagnosis of native valve endocarditis (NVE).
Selected articles evaluating the diagnostic accuracy of <sup>18</sup> F-FDG PET/CT in patients with suspected NVE, resulting from a comprehensive literature search through the PubMed/MEDLINE and Cochrane library databases until April 2020, were included for the systematic review and meta-analysis.
Seven studies (351 episodes of suspected NVE) were included. <sup>18</sup> F-FDG PET/CT yielded a pooled sensitivity of 36.3% and a pooled specificity of 99.1% for the diagnosis of NVE. The pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 8.3, 0.6, and 15.3, respectively. The sensitivity increased using contemporary PET/CT device with state-of-the-art patient preparation as well as innovative image acquisitions or adding the results of <sup>18</sup> F-FDG PET/CT in a multimodality strategy.
In our systematic review and meta-analysis, <sup>18</sup> F-FDG PET/CT yielded a poor pooled sensitivity with an otherwise excellent pooled specificity for the diagnosis of NVE; however, several factors may increase the sensitivity without affecting the specificity and these factors should be better evaluated in future studies.
Keywords
18F-FDG, PET/CT, diagnostic performance, infectious diseases, infectious endocarditis, meta-analysis, native valve endocarditis, positron emission tomography, systematic review.
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2020 11:54
Last modification date
15/01/2021 6:24
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