Zum Problem des Atemwegskollapses beim Lungenemphysem. Korrelation zwischen intravitalen Lungenfunktionsgrossen und morphometrischen Daten. [The problem of airway collapse in lung emphysema. Correlation between intravital lung function measurements and morphometric data]

Details

Serval ID
serval:BIB_BC30ECF92A3A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Zum Problem des Atemwegskollapses beim Lungenemphysem. Korrelation zwischen intravitalen Lungenfunktionsgrossen und morphometrischen Daten. [The problem of airway collapse in lung emphysema. Correlation between intravital lung function measurements and morphometric data]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Dalquen  P., Oberholzer  M., von Segesser  L., Perruchoud  A., Herzog  H., Rohr  H. P.
ISSN
0036-7672
Publication state
Published
Issued date
02/1978
Peer-reviewed
Oui
Volume
108
Number
8
Pages
293-9
Notes
English Abstract
Journal Article --- Old month value: Feb 25
Abstract
Lowering of forced expired volume in one second as a percentage of vital capacity (FEV1%VC) and check-valve phenomenon of expiratory flow curve (CVPh) are clinical signs of bronchial collapse. In this study the correlations between these functional parameters and morphologic findings are studied. The study comprises autopsy cases in which lung function had been tested 1.5 years on average before death. In 138 cases emphysema was graded on papermounted macrosections and in 52 cases bronchi were studied by morphometry. 19 of the latter were analysed more thoroughly; 9 had shown CVPh. The results were as follows: 1. Collapse phenomena occur more frequently in cases with destructive emphysema than in cases without. However, it is not exclusive to the former. 2. FEV1 and CVPh correlate with hypertrophy of bronchial glands. 3. Cases with CVPh show hypertrophy, not atrophy, of the walls of central bronchi. It follows that bronchial collapse phenomena are mainly influenced by increased bronchial secretion of viscous mucus and not by emphysematous destruction of lung parenchyma. On forced expiration, mucus plugging probably leads to a decrease of intrabronchial pressure in the downstream bronchi. Thus, the downstream bronchi may collapse because the equal pressure point between intrabronchial and intrathoracic pressure shifts from the central to more peripheral bronchi.
Keywords
Bronchi/pathology Emphysema/*physiopathology Forced Expiratory Volume Humans Lung/*pathology Vital Capacity
Pubmed
Web of science
Create date
14/02/2008 14:18
Last modification date
20/08/2019 15:30
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