Effect of low-dose chest irradiation before chemotherapy on the rate of local failure in small-cell lung cancer.
Details
Serval ID
serval:BIB_BC276C1B0CDC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of low-dose chest irradiation before chemotherapy on the rate of local failure in small-cell lung cancer.
Journal
International journal of radiation oncology, biology, physics
ISSN
0360-3016
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
41
Number
2
Pages
287-9
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
PURPOSE: To evaluate the rate of tumor recurrence within the irradiated volume after initial low-dose irradiation of limited-stage small-cell lung cancer (SCLC), to assess the tolerance of a sequential combination of low-dose chest irradiation followed by chemotherapy, and to confirm the responsiveness of limited-stage SCLC to low-dose irradiation. METHODS AND MATERIALS: In this pilot study, 26 patients with limited-stage SCLC were treated by first-line 20-Gy thoracic irradiation followed 3 weeks later by chemotherapy (cisplatin, doxorubicin, and etoposide for six cycles). RESULTS: We present our final results with a median follow-up of surviving patients of 7 years. The response rate to this low-dose irradiation was 83%, with an overall response rate to radiochemotherapy of 96% and a median survival of 21 months. No unexpected early or late toxicity was observed. The rate of initial isolated local failure was 8%, which compares favorably with other published series using higher doses of radiochemotherapy. CONCLUSION: An initial chest irradiation of 20 Gy before chemotherapy could be sufficient to reduce the risk of local failure during the time of survival of patients with limited-stage SCLC. Potential advantages of this treatment may be the prevention of resistance mechanisms to radiotherapy induced by preliminary chemotherapy and a reduced radiation-induced toxicity.
Keywords
Aged, Carcinoma, Small Cell, Combined Modality Therapy, Female, Humans, Lung Neoplasms, Male, Middle Aged, Pilot Projects, Radiotherapy Dosage, Survival Analysis, Treatment Failure
Pubmed
Web of science
Create date
24/01/2008 17:12
Last modification date
20/08/2019 15:30