Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers.

Details

Serval ID
serval:BIB_BC20EAA5649D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Post-H1N1 Flu Vaccination Narcolepsy in Switzerland: A Retrospective Survey in the 30 Sleep-Certified Swiss Centers.
Journal
European Neurology
Author(s)
Kallweit U., Mathis J., Jenni O.G., Heinzer R., Haba-Rubio J., Baumann C.R., Cervena K., Bassetti C.L.
ISSN
1421-9913 (Electronic)
ISSN-L
0014-3022
Publication state
Published
Issued date
2016
Volume
75
Number
3-4
Pages
105-108
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Narcolepsy-cataplexy is a sleep-wake disorder and suggested to be immune-mediated, involving genetic and environmental factors. The autoimmune process eventually leads to a loss of hypocretin neurons in the lateral hypothalamus. Epidemiological studies in several countries proved an increased incidence of narcolepsy after H1N1 flu vaccination and infection. This survey in 30 sleep centers in Switzerland led to the identification of 9 H1N1-vaccinated children and adults as newly diagnosed narcolepsy. Clinical features included the abrupt and severe onset of sleepiness, cataplexy and sleep fragmentation.
Pubmed
Create date
24/04/2016 10:35
Last modification date
19/11/2019 7:26
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