Programming of Cardiovascular Dysfunction by Postnatal Overfeeding in Rodents.

Details

Serval ID
serval:BIB_BC19345669D9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Programming of Cardiovascular Dysfunction by Postnatal Overfeeding in Rodents.
Journal
International journal of molecular sciences
Author(s)
Josse M., Rigal E., Rosenblatt-Velin N., Rochette L., Zeller M., Guenancia C., Vergely C.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
11/12/2020
Peer-reviewed
Oui
Volume
21
Number
24
Pages
E9427
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Nutritional environment in the perinatal period has a great influence on health and diseases in adulthood. In rodents, litter size reduction reproduces the effects of postnatal overnutrition in infants and reveals that postnatal overfeeding (PNOF) not only permanently increases body weight but also affects the cardiovascular function in the short- and long-term. In addition to increased adiposity, the metabolic status of PNOF rodents is altered, with increased plasma insulin and leptin levels, associated with resistance to these hormones, changed profiles and levels of circulating lipids. PNOF animals present elevated arterial blood pressure with altered vascular responsiveness to vasoactive substances. The hearts of overfed rodents exhibit hypertrophy and elevated collagen content. PNOF also induces a disturbance of cardiac mitochondrial respiration and produces an imbalance between oxidants and antioxidants. A modification of the expression of crucial genes and epigenetic alterations is reported in hearts of PNOF animals. In vivo, a decreased ventricular contractile function is observed during adulthood in PNOF hearts. All these alterations ultimately lead to an increased sensitivity to cardiac pathologic challenges such as ischemia-reperfusion injury. Nevertheless, caloric restriction and physical exercise were shown to improve PNOF-induced cardiac dysfunction and metabolic abnormalities, drawing a path to the potential therapeutic correction of early nutritional programming.
Keywords
arteries, cardiovascular dysfunction, heart, ischemia, perinatal programming, postnatal overfeeding, rodents
Pubmed
Web of science
Open Access
Yes
Create date
22/12/2020 10:01
Last modification date
23/02/2022 7:36
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