Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo.

Details

Serval ID
serval:BIB_BBB211133D3E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo.
Journal
Virology
Author(s)
Rojek J.M., Spiropoulou C.F., Kunz S.
ISSN
0042-6822 (Print)
ISSN-L
0042-6822
Publication state
Published
Issued date
2006
Volume
349
Number
2
Pages
476-491
Language
english
Abstract
The New World arenaviruses Junin, Machupo, and Guanarito are the causative agents of hemorrhagic fevers (HF) with high mortality in humans. The cellular receptor for Old World arenaviruses and one subgroup of the New World arenaviruses (Clade C) have been identified as alpha-dystroglycan (alpha-DG). In contrast, the receptor(s) of the South American HF viruses, which belong to the Clade B New World arenaviruses, are currently unknown. To begin to characterize the cellular receptors used by these pathogens, we generated recombinant retroviral pseudotypes with the glycoproteins of Guanarito, Junin, and Machupo. Infection with the South American HF viruses is independent of alpha-DG and functional receptors for Guanarito, Junin, and Machupo were found on most human cell types and cells derived from non-human primate and rodents. Guanarito, Junin, and Machupo share a common receptor, which is distinct from the receptor(s) used by the closely related non-pathogenic Clade B virus Amapari, and the genetically more distant Clade A and C New World arenaviruses. We show that the cellular receptor(s) for the South American HF viruses are proteins or protein-linked entities and that infection is not dependent on protein-linked N-glycans, O-glycans, or glycosaminoglycans.
Keywords
Animals, Arenaviruses, New World/metabolism, Cell Line, Cercopithecus aethiops, Cricetinae, Humans, Junin virus/metabolism, Membrane Proteins/metabolism, Mice, Polysaccharides/physiology, Protein Binding, Receptors, Virus/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
17/04/2013 11:56
Last modification date
20/08/2019 15:29
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