Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens.

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State: Public
Version: Final published version
Serval ID
serval:BIB_BBA0D164F4AC
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Title
Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens.
Journal
Ecology Letters
Author(s)
Vijendravarma R.K., Narasimha S., Chakrabarti S., Babin A., Kolly S., Lemaitre B., Kawecki T.J.
ISSN
1461-0248 (Electronic)
ISSN-L
1461-023X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
18
Number
10
Pages
1078-1086
Language
english
Abstract
The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unknown whether these functions can be independently optimised by evolution, or whether they interfere with each other. We report that Drosophila melanogaster populations adapted during 160 generations of experimental evolution to chronic larval malnutrition became more susceptible to intestinal infection with the opportunistic bacterial pathogen Pseudomonas entomophila. However, they do not show suppressed immune response or higher bacterial loads. Rather, their increased susceptibility to P. entomophila is largely mediated by an elevated predisposition to loss of intestinal barrier integrity upon infection. These results may reflect a trade-off between the efficiency of nutrient extraction from poor food and the protective function of the gut, in particular its tolerance to pathogen-induced damage.
Keywords
Adaptation, Drosophila, enteric infections, experimental evolution, host-parasite interactions, innate immunity, nutritional stress, Pseudomonas entomophila, stress tolerance, trade-offs
Pubmed
Web of science
Open Access
Yes
Create date
21/09/2015 16:03
Last modification date
20/08/2019 16:29
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