Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community.

Details

Ressource 1Download: 29965943.pdf (464.67 [Ko])
State: Public
Version: Author's accepted manuscript
License: Not specified
Secondary document(s)
Download: 29965943_cover.pdf (697.54 [Ko])
State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_BB93B1AA4662
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community.
Journal
Psychosomatic medicine
Author(s)
Gebreab S.Z., Vandeleur C.L., Rudaz D., Strippoli M.F., Gholam-Rezaee M., Castelao E., Lasserre A.M., Glaus J., Pistis G., Kuehner C., von Känel R., Marques-Vidal P., Vollenweider P., Preisig M.
ISSN
1534-7796 (Electronic)
ISSN-L
0033-3174
Publication state
Published
Issued date
09/2018
Peer-reviewed
Oui
Volume
80
Number
7
Pages
628-639
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The complex relationship between psychosocial stress over the lifetime, psychological factors, and cardiometabolic risk is still poorly understood. Accordingly, our aims were (1) to independently assess the associations between childhood adversity, life-event stress in remote (earlier than the last 5 years), and recent adulthood and cardiometabolic risk, and (2) to determine the role of psychological factors including personality, coping, and depression in these associations.
The sample included 2674 adults, aged 35 to 66 years, randomly selected from urban area. Participants underwent a physical examination including the assessment of obesity markers, blood pressure, and blood lipid and glucose levels. Stress during adulthood was determined using the severity scores of 52 stressful life events. Information on adverse childhood experiences and major depressive disorders was collected using semistructured interviews, whereas personality traits and coping mechanisms were evaluated through questionnaires.
Both childhood adversity and stress in remote adulthood were associated with elevated body mass index (β [95% confidence interval {CI}] = 0.249 [0.029 to 0.468]; 0.020 [0.006 to 0.034]), waist circumference (β [95% CI] = 0.061 [0.024 to 0.099]; 0.08 [0.04 to 0.11]), and the global cardiometabolic risk score (β [95% CI] = 0.278 [0.017 to 0.540]; 0.017 [0.001 to 0.033]) after adjustment for sociodemographic, lifestyle, and psychological factors. In addition, childhood adversity was associated with low high density lipoprotein levels (β [95% CI] = -0.021 [-0.042 to 0.000]), as well as increased fat mass and systolic blood pressure levels (β [95% CI] = 0.506 [0.165 to 0.846]; 0.952 [0.165 to 1.740]) and stress in remote adulthood with apolipoprotein B levels (β [95% CI] = 0.607 [0.312 to 0.901]). Psychological factors did not account for these associations and were not effect modifiers.
Our data demonstrate that psychosocial stress during childhood and remote adulthood favor adiposity and abnormal lipid metabolism.
Keywords
Adaptation, Psychological/physiology, Adult, Adverse Childhood Experiences/statistics & numerical data, Aged, Body Mass Index, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/physiopathology, Cohort Studies, Depressive Disorder, Major/blood, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/physiopathology, Female, Humans, Male, Metabolic Diseases/blood, Metabolic Diseases/epidemiology, Metabolic Diseases/physiopathology, Middle Aged, Personality/physiology, Risk, Stress, Psychological/blood, Stress, Psychological/epidemiology, Stress, Psychological/physiopathology, Switzerland/epidemiology, Waist Circumference/physiology
Pubmed
Web of science
Create date
10/07/2018 14:55
Last modification date
27/09/2019 8:49
Usage data