The aged lymphoid tissue environment fails to support naïve T cell homeostasis.

Details

Serval ID
serval:BIB_BB8CB3EE7379
Type
Article: article from journal or magazin.
Collection
Publications
Title
The aged lymphoid tissue environment fails to support naïve T cell homeostasis.
Journal
Scientific reports
Author(s)
Becklund B.R., Purton J.F., Ramsey C., Favre S., Vogt T.K., Martin C.E., Spasova D.S., Sarkisyan G., LeRoy E., Tan J.T., Wahlus H., Bondi-Boyd B., Luther S.A., Surh C.D.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
02/08/2016
Peer-reviewed
Oui
Volume
6
Pages
30842
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Aging is associated with a gradual loss of naïve T cells and a reciprocal increase in the proportion of memory T cells. While reduced thymic output is important, age-dependent changes in factors supporting naïve T cells homeostasis may also be involved. Indeed, we noted a dramatic decrease in the ability of aged mice to support survival and homeostatic proliferation of naïve T cells. The defect was not due to a reduction in IL-7 expression, but from a combination of changes in the secondary lymphoid environment that impaired naïve T cell entry and access to key survival factors. We observed an age-related shift in the expression of homing chemokines and structural deterioration of the stromal network in T cell zones. Treatment with IL-7/mAb complexes can restore naïve T cell homeostatic proliferation in aged mice. Our data suggests that homeostatic mechanisms that support the naïve T cell pool deteriorate with age.
Keywords
Animals, Cell Proliferation, Homeostasis/physiology, Immunologic Memory/immunology, Lymphocyte Activation/immunology, Lymphoid Tissue/immunology, Mice, Mice, Inbred C57BL, T-Lymphocyte Subsets/immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/08/2016 14:04
Last modification date
20/08/2019 15:29
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