Sleep Characteristics in Early Stages of Chronic Kidney Disease in the HypnoLaus Cohort.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: author
Serval ID
serval:BIB_BB4D0794CCF2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sleep Characteristics in Early Stages of Chronic Kidney Disease in the HypnoLaus Cohort.
Journal
Sleep
Author(s)
Ogna A., Forni Ogna V., Haba Rubio J., Tobback N., Andries D., Preisig M., Tafti M., Vollenweider P., Waeber G., Marques-Vidal P., Heinzer R.
ISSN
1550-9109 (Electronic)
ISSN-L
0161-8105
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
39
Number
4
Pages
945-953
Language
english
Abstract
STUDY OBJECTIVES: To evaluate the association between early stages of chronic kidney disease (CKD) and sleep disordered breathing (SDB), restless legs syndrome (RLS), and subjective and objective sleep quality (SQ).
METHODS: Cross-sectional analysis of a general population-based cohort (HypnoLaus). 1,760 adults (862 men, 898 women; age 59.3 (± 11.4) y) underwent complete polysomnography at home.
RESULTS: 8.2% of participants had mild CKD (stage 1-2, estimated glomerular filtration rate [eGFR] ≥ 60 mL/min/1.73 m(2) with albuminuria) and 7.8% moderate CKD (stage 3, eGFR 30-60 mL/min/1.73 m(2)). 37.3% of our sample had moderate-to-severe SDB (apnea-hypopnea index [AHI] ≥ 15/h) and 15.3% had severe SDB (AHI ≥ 30/h). SDB prevalence was positively associated with CKD stages and negatively with eGFR. In multivariate analysis, age, male sex, and body mass index were independently associated with SDB (all P < 0.001), but kidney function was not. The prevalence of RLS was 17.5%, without difference between CKD stages. Periodic leg movements index (PLMI) was independently associated with CKD stages. Subjective and objective SQ decreased and the use of sleep medication was more frequent with declining kidney function. Older age, female sex, and the severity of SDB were the strongest predictors of poor SQ in multivariate regression analysis but CKD stage was also independently associated with reduced objective SQ.
CONCLUSIONS: Patients with early stages of CKD have impaired SQ, use more hypnotic drugs, and have an increased prevalence of SDB and PLM. After controlling for confounders, objective SQ and PLMI were still independently associated with declining kidney function.
Keywords
chronic kidney disease, periodic leg movements during sleep, polysomnography, restless legs syndrome, sleep apnea, sleep disordered breathing, sleep quality
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2016 11:28
Last modification date
20/08/2019 15:29
Usage data