Toward a unified approach to genetic mapping of eukaryotes based on sequence tagged microsatellite sites
Details
Serval ID
serval:BIB_BB4198124CBB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Toward a unified approach to genetic mapping of eukaryotes based on sequence tagged microsatellite sites
Journal
Bio/Technology
ISSN
0733-222X (Print)
Publication state
Published
Issued date
10/1990
Volume
8
Number
10
Pages
930-2
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Oct
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Oct
Abstract
The genomes of all eukaryotes appear to contain a special class of loci, termed microsatellites, which can serve, if sequenced and taken as the substrate for the polymerase chain reaction, as highly informative, locus-specific markers. By analogy to the "sequence tagged sites" recently proposed by Olsen et al. for standardizing the human physical gene map, these microsatellite markers are termed "sequence tagged microsatellite sites" (STMS). Genetic maps based on STMS will share with the Olsen physical maps the advantage that mapping vocabularies will be standardized to the DNA sequence base and that access to any particular locus will not require shipping or storing cloned probes. The species map will consist simply of a listing of nucleotide sequences. Reference populations for developing STMS maps can be chosen on the basis of biological or economic interest. It will not be necessary to maximize for genetic divergence.
Keywords
Animals
Chromosome Mapping/*methods
Dna
*Eukaryotic Cells
Genetic Markers/genetics
Humans
Polymerase Chain Reaction
Polynucleotides
*Repetitive Sequences, Nucleic Acid
Pubmed
Web of science
Create date
25/01/2008 16:17
Last modification date
20/08/2019 15:29