Molecular Evolution and Gene Function

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Ressource 1Download: Robinson-Rechavi - 2020 - Molecular Evolution and Gene Function.pdf (624.58 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_BB2B81C3E623
Type
A part of a book
Collection
Publications
Title
Molecular Evolution and Gene Function
Title of the book
Phylogenetics in the Genomic Era
Author(s)
Robinson-Rechavi Marc
Publisher
hal.inria.fr
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Language
english
Abstract
One of the basic questions of phylogenomics is how gene function evolves, whether among species or inside gene families. In this chapter, we provide a brief overview of the problems associated with defining gene function in a manner which allows comparisons which are both large scale and evolutionarily relevant. The main source of functional data, despite its limitations, is transcrip-tomics. Functional data provides information on evolutionary mechanisms primarily by showing which functional classes of genes evolve under stronger or weaker purifying or adaptive selection, and on which classes of mutations (e.g., substitutions or duplications). However, the example of the "ortholog conjecture" shows that we are still not at a point where we can confidently study phylogenomically the evolution of gene function at a precise scale.
Create date
15/04/2020 11:48
Last modification date
16/04/2020 7:09
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