Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_BB13B9FF12B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms.
Journal
Nutrients
Author(s)
Cuenoud B., Rochat I., Gosoniu M.L., Dupuis L., Berk E., Jaudszus A., Mainz J.G., Hafen G., Beaumont M., Cruz-Hernandez C.
ISSN
2072-6643 (Electronic)
ISSN-L
2072-6643
Publication state
Published
Issued date
07/04/2020
Peer-reviewed
Oui
Volume
12
Number
4
Pages
1014
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy depend on numerous factors, including OM3 form, food matrix effects (especially the lipid content of the diet), and metabolic capacity. Here, we show in humans that a "pre-digested" OM3-sn-1(3)-monoacylglycerol lipid structure (OM3-MAG) has a significantly greater absorption at high therapeutic doses (2.9 g/day) than the most commonly OM3-ethyl ester (3.1 g/day) form (used for the treatment of hypertriglyceridemia), and a comparable profile to other pre-digested OM3 free fatty acids (OM3-FFA) structure (3.2 g/day). Nutritional supplement doses of MAG resulted in similar increases in OM3 blood level, compared to OM3 triacylglycerols (OM3-TAG) supplements in obese subjects (1.2 g/day) under low fat diet, and in children with cystic fibrosis (1.0 g/day). These results suggest that both forms of pre-digested OM3-MAG and OM3-FFA are effectively absorbed and re-incorporated effectively into triacylglycerols inside the enterocytes, before being exported into the chylomicrons lipid transport system. The pre-digested OM3-MAG might provide a more effective therapy in severe cardiovascular conditions where high doses of OM3 are required and a low-fat diet is indicated, which limited digestive lipase activity.
Keywords
cystic fibrosis, fatty acid digestion, hypertriglyceridemia, lipid absorption, obesity, omega 3, omega-3 sn-1(3)-monoacylglycerol
Pubmed
Open Access
Yes
Create date
25/04/2020 21:32
Last modification date
23/01/2021 7:21
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