Strong impact of smoking on multimorbidity and cardiovascular risk among human immunodeficiency virus-infected individuals in comparison with the general population.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_BB00A4302053
Type
Article: article from journal or magazin.
Collection
Publications
Title
Strong impact of smoking on multimorbidity and cardiovascular risk among human immunodeficiency virus-infected individuals in comparison with the general population.
Journal
Open Forum Infectious Diseases
Author(s)
Hasse B., Tarr P.E., Marques-Vidal P., Waeber G., Preisig M., Mooser V., Valeri F., Djalali S., Andri R., Bernasconi E., Calmy A., Cavassini M., Vernazza P., Battegay M., Weber R., Senn O., Vollenweider P., Ledergerber B., FIRE 
Working group(s)
CoLaus Cohort
Contributor(s)
Aubert V., Barth J., Battegay M., Bernasconi E., Böni J., Bucher H.C., Burton-Jeangros C., Calmy A., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Metzner K., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schöni-Affolter F., Schmid P., Schultze D., Schüpbach J., Speck R., Staehelin C., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S., Aubert V., Barth J., Battegay M., Bernasconi E., Böni J., Bucher H.C., Burton-Jeangros C., Calmy A., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Metzner K., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schöni-Affolter F., Schmid P., Schultze D., Schüpbach J., Speck R., Staehelin C., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S., Jean-Michel A., Murielle B., Jean Michel G., Christoph H., Thomas L., Pedro M.V., Vincent M., Fred P., Martin P., Peter V., Roland V.K., Aidacic V., Gerard W., Jürg B., Markus B., Heinz B., Martin B., Hans-Ulrich B., Ivo B., Reto C., Isabelle C., Corinne C., Sima D., Peter D., Simone E., Andrea F., Markus F., Claudius F., Jakob F., Ali G.M., Matthias G., Denis H., Marcel H., Walter H., Simon H., Felix H., Paul H., Eva K., Vladimir K., Daniel K., Stephan K., Beat K., Benedict K., Heidi K., Vesna L., Giovanni L., Werner L.H., Phillippe L., Severin L., Christoph M., Jürgen M., Damian M., Werner M., Titus M., Valentina N., Jakob R., Thomas R., Hana S., Frank S., Georg S., Oliver S., Pietro S., Jacques S., Alfred S., Alois S., Claudia S., Othmar S., Phuoc T.T., Marco V., Alessandro V., René V.A., Hans W., Fritz W., Johanna W.S., Joseph W., Marco Z.
ISSN
2328-8957 (Electronic)
ISSN-L
2328-8957
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
2
Number
3
Pages
ofv108
Language
english
Notes
Publication Status: epublish
Abstract
Background.  Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods.  We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records. The incidence of the respective endpoints were assessed among SHCS and CoLaus participants. Poisson regression models were adjusted for age, sex, body mass index, and smoking. Results.  Overall, 74 291 participants contributed data to prevalence analyses (3230 HIV-infected; 71 061 controls). In CoLaus, FIRE, and SHCS, multimorbidity was present among 26%, 13%, and 27% of participants. Compared with nonsmoking individuals from CoLaus, the incidence of cardiovascular disease was elevated among smoking individuals but independent of HIV status (HIV-negative smoking: incidence rate ratio [IRR] = 1.7, 95% confidence interval [CI] = 1.2-2.5; HIV-positive smoking: IRR = 1.7, 95% CI = 1.1-2.6; HIV-positive nonsmoking: IRR = 0.79, 95% CI = 0.44-1.4). Compared with nonsmoking HIV-negative persons, multivariable Poisson regression identified associations of HIV infection with hypertension (nonsmoking: IRR = 1.9, 95% CI = 1.5-2.4; smoking: IRR = 2.0, 95% CI = 1.6-2.4), kidney (nonsmoking: IRR = 2.7, 95% CI = 1.9-3.8; smoking: IRR = 2.6, 95% CI = 1.9-3.6), and liver disease (nonsmoking: IRR = 1.8, 95% CI = 1.4-2.4; smoking: IRR = 1.7, 95% CI = 1.4-2.2). No evidence was found for an association of HIV-infection or smoking with diabetes mellitus. Conclusions.  Multimorbidity is more prevalent and incident in HIV-positive compared with HIV-negative individuals. Smoking, but not HIV status, has a strong impact on cardiovascular risk and multimorbidity.
Pubmed
Open Access
Yes
Create date
11/09/2015 9:58
Last modification date
20/08/2019 16:29
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