Immunogénicité comparée de deux vaccins antirabiques dans un schéma de vaccination post-expositionnelle 2-1-1 [Comparative immunogenicity of 2 antirabies vaccines in a 2-1-1 post-exposure vaccination schedule]

Details

Serval ID
serval:BIB_BAE36DD15187
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunogénicité comparée de deux vaccins antirabiques dans un schéma de vaccination post-expositionnelle 2-1-1 [Comparative immunogenicity of 2 antirabies vaccines in a 2-1-1 post-exposure vaccination schedule]
Journal
Praxis
Author(s)
Landry P., Lazzaro M., Darioli R.
ISSN
1661-8157
Publication state
Published
Issued date
1998
Volume
87
Number
37
Pages
1177-1179
Language
french
Abstract
Few trials have compared the Purified Duck Embryo Vaccine (PDEV) and the Human Diploid Cell Vaccine (HDCV) in a post-exposure immunization schedule of 4 shots (2 on day 0 and 1 each on day 7 and 21, or 2-1-1 schedule). A retrospective analysis compared 10 patients with PEDV and 20 with HDCV, who had received the 2-1-1 schedule as well as 20 UI mg/kg of immune globulins on day 0. The median neutralizing antibody titers on day 21 (after 3 doses) and the median of maximum titers until day 90 were higher for HDCV than for PEDV (0.6 IU/ml versus 3.5 IU/ml [p < 0.04] and 2.5 IU/ml versus 5.8 IU/ml [p < 0.03] respectively). Seven patients had not reached the seroconversion titer of 0.5 IU/ml after 3 doses (day 21). These results differ from previous studies showing a 100% seroconversion rate on day 21, and suggest that more studies are required before these 2 vaccines can be used in the 2-1-1 schedule after severe exposure.
Keywords
Adult, Antibodies, Viral, Female, Humans, Immunization Schedule, Male, Rabies, Rabies Vaccines, Rabies virus, Retrospective Studies
Pubmed
Create date
28/01/2008 11:45
Last modification date
20/08/2019 15:28
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