Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.

Details

Serval ID
serval:BIB_BAA724EC522D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma.
Journal
Journal of the American Academy of Dermatology
Author(s)
DeSimone J.A., Guenova E. (co-first), Carter J.B., Chaney K.S., Aldridge J.R., Noell C.M., Dorosario A.A., Hansen J.L., Kupper T.S., Devlin P.M.
ISSN
1097-6787 (Electronic)
ISSN-L
0190-9622
Publication state
Published
Issued date
07/2013
Peer-reviewed
Oui
Volume
69
Number
1
Pages
61-65
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity.
Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose high-dose-rate surface applicator brachytherapy and to examine the overall clinical response to brachytherapy.
A total of 23 facial MF lesions in 10 patients were treated with high-dose-rate brachytherapy doses of 4 Gy per session for a total of 2 fractions at our multidisciplinary cutaneous oncology clinic between August 17, 2009, and March 12, 2012.
In all 23 lesions, dramatic clinical improvement was observed. Patients were followed up for a median of 6.3 months. No recurrences were reported in the follow-up period.
Long-term follow-up is lacking. Reassessment of all included patients at annual intervals for a period of at least 5 years is the authors' goal.
Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF.
Keywords
Aged, Aged, 80 and over, Brachytherapy/methods, Dose-Response Relationship, Radiation, Erythema/etiology, Facial Neoplasms/radiotherapy, Female, Humans, Male, Middle Aged, Mycosis Fungoides/radiotherapy, Radiotherapy/adverse effects, Radiotherapy Dosage, Skin Neoplasms/radiotherapy, Treatment Outcome
Pubmed
Web of science
Create date
27/08/2020 13:59
Last modification date
27/10/2020 21:19
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