Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania.
Details
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State: Public
Version: Final published version
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State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_BA7273F518DF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania.
Journal
Malaria journal
ISSN
1475-2875 (Electronic)
ISSN-L
1475-2875
Publication state
Published
Issued date
19/12/2006
Peer-reviewed
Oui
Volume
5
Pages
126
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa. However, their long-term usefulness in these high transmission areas remains unclear. It has been suggested that documentation of the S769N PfATPase6 mutations may indicate an emergence of artemisinin resistance of Plasmodium falciparum in the field. The present study assessed PfATPase6 mutations (S769N and A623E) in 615 asymptomatic P. falciparum infections in Tanzania but no mutant genotype was detected. This observation suggests that resistance to artemisinin has not yet been selected in Tanzania, supporting the Ministry of Health's decision to adopt artemether+lumefantrine as first-line malaria treatment. The findings recommend further studies to assess PfATPase6 mutations in sentinel sites and verify their usefulness in monitoring emergency of ACT resistance.
Keywords
Animals, Antimalarials/pharmacology, Artemisinins/pharmacology, Drug Resistance, Humans, Plasmodium falciparum/drug effects, Plasmodium falciparum/genetics, Plasmodium falciparum/isolation & purification, Polymerase Chain Reaction, Sesquiterpenes/pharmacology, Tanzania
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:48
Last modification date
09/08/2024 6:30