Effects of alcohol consumption on human hippocampus anatomy

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State: Public
Version: After imprimatur
License: Not specified
Serval ID
serval:BIB_BA676EC3279F
Type
A Master's thesis.
Publication sub-type
Master (thesis) (master)
Collection
Publications
Institution
Title
Effects of alcohol consumption on human hippocampus anatomy
Author(s)
FENTER F.
Director(s)
DRAGANSKI B.
Institution details
Université de Lausanne, Faculté de biologie et médecine
Publication state
Accepted
Issued date
2019
Language
english
Number of pages
33
Abstract
The hippocampus is a brain structure consisting of a dense layer of neurons at the mesial surface of the temporal lobe. It is part of the limbic system and has been shown to be essential for the consolidation of long-term memory. There is ample evidence of a link between MRI hippocampal volume and memory (1), and in broader sense - cognitive performance (2). The hippocampus projections reach limbic structures - prefrontal cortex, amygdala and accumbens nuclei to then form the Papez circuit, essential for emotional response. The hippocampus connectivity patterns and central position in a number of functional networks explain its involvement in psychiatric disorders - depression and schizophrenia(3). Its specific vulnerability to lack of oxygen and neurodegeneration has made it one of the most extensively studied structures in the human central nervous system. Hippocampal damage has been linked to several neuropsychiatric disorders - Alzheimer’s disease, epilepsy, drug abuse, depression and schizophrenia, to name but a few. Each of these is related to structural changes in hippocampal anatomy. The study of alcohol use makes particular sense as some of the symptoms of chronic alcoholism affect functions attributed to the hippocampus, particularly emotional/motivational and cognitive functions, which are known to be modulated by the hippocampus (4).
Create date
03/09/2020 15:29
Last modification date
07/10/2020 6:26
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