A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.

Details

Serval ID
serval:BIB_BA660528AA2B
Type
Article: article from journal or magazin.
Collection
Publications
Title
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.
Journal
Cancer Cell
Author(s)
Sflomos G., Dormoy V., Metsalu T., Jeitziner R., Battista L., Scabia V., Raffoul W., Delaloye J.F., Treboux A., Fiche M., Vilo J., Ayyanan A., Brisken C.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
29
Number
3
Pages
407-422
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenografts (PDXs) are hard to establish. We show that the traditional grafting of ER(+) tumor cells into mammary fat pads induces TGFβ/SLUG signaling and basal differentiation when they require low SLUG levels to grow in vivo. Grafting into the milk ducts suppresses SLUG; ER(+) tumor cells develop, like their clinical counterparts, in the presence of physiological hormone levels. Intraductal ER(+) PDXs are retransplantable, predictive, and appear genomically stable. The model provides opportunities for translational research and the study of physiologically relevant hormone action in breast carcinogenesis.
Pubmed
Web of science
Open Access
Yes
Create date
08/03/2016 15:23
Last modification date
20/08/2019 16:28
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