Impact of semen microbiota on the composition of seminal plasma.
Details
Serval ID
serval:BIB_BA5225B0ECB6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of semen microbiota on the composition of seminal plasma.
Journal
Microbiology spectrum
ISSN
2165-0497 (Electronic)
ISSN-L
2165-0497
Publication state
Published
Issued date
05/03/2024
Peer-reviewed
Oui
Volume
12
Number
3
Pages
e0291123
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Several studies have found associations between specific bacterial genera and semen parameters. Bacteria are known to influence the composition of their niche and, consequently, could affect the composition of the seminal plasma. This study integrated microbiota profiling and metabolomics to explore the influence of seminal bacteria on semen metabolite composition in infertile couples, revealing associations between specific bacterial genera and metabolite profiles. Amino acids and acylcarnitines were the predominant metabolite groups identified in seminal plasma. Different microbiota profiles did not result in globally diverse metabolite compositions in seminal plasma. Nevertheless, levels of specific metabolites increased in the presence of a dysbiotic microbiota. Urocanate was significantly increased in abnormal semen samples (adjusted P-value < 0.001) and enriched in samples dominated by Prevotella spp. (P-value < 0.05), which was previously linked to a negative impact on semen. Therefore, varying microbiota profiles can influence the abundance of certain metabolites, potentially having an immunomodulatory effect, as seen with urocanate.IMPORTANCEMale infertility is often considered idiopathic since the specific cause of infertility often remains unidentified. Recently, variations in the seminal microbiota composition have been associated with normal and abnormal semen parameters and may, therefore, influence male infertility. Bacteria are known to alter the metabolite composition of their ecological niches, and thus, seminal bacteria might affect the composition of the seminal fluid, crucial in the fertilization process. Our research indicates that distinct seminal microbiota profiles are not associated with widespread changes in the metabolite composition of the seminal fluid. Instead, the presence of particular metabolites with immunomodulatory functions, such as urocanate, could shed light on the interplay between seminal microbiota and variations in semen parameters.
Keywords
Humans, Male, Semen/chemistry, Semen/metabolism, Semen/microbiology, Infertility, Male/metabolism, Infertility, Male/microbiology, Body Fluids, Microbiota, Metabolomics, infertility, seminal fluid, seminal microbiota
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2024 17:48
Last modification date
09/08/2024 16:05