Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases.
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State: Public
Version: Final published version
State: Public
Version: Final published version
Serval ID
serval:BIB_BA22DDB12242
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk factors for gallstones and kidney stones in a cohort of patients with inflammatory bowel diseases.
Journal
PloS one
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
12
Number
10
Pages
e0185193
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications.
Identifying risk factors for gallstones and kidney stones in IBD patients.
Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses.
Out of 2323 IBD patients, 104 (7.8%) Crohn's disease (CD) and 38 (3.8%) ulcerative colitis (UC) patients were diagnosed with gallstones. Significant risk factors for gallstones were diagnosis of CD, age at diagnosis, disease activity and duration, NSAID intake, extra-intestinal manifestations and intestinal surgery. Kidney stones were described in 61 (4.6%) CD and 30 (3.0%) UC patients. Male gender, disease activity, intestinal surgery, NSAID usage and reduced physical activity were significant risk factors. Hospitalization was associated with gallstones and kidney stones. The presence of gallstones increased the risk for kidney stones (OR 4.87, p<0.001).
The diagnosis of CD, intestinal surgery, prolonged NSAID use, disease activity and duration and bowel stenosis were significantly associated with cholecystonephrolithiasis in IBD.
Identifying risk factors for gallstones and kidney stones in IBD patients.
Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses.
Out of 2323 IBD patients, 104 (7.8%) Crohn's disease (CD) and 38 (3.8%) ulcerative colitis (UC) patients were diagnosed with gallstones. Significant risk factors for gallstones were diagnosis of CD, age at diagnosis, disease activity and duration, NSAID intake, extra-intestinal manifestations and intestinal surgery. Kidney stones were described in 61 (4.6%) CD and 30 (3.0%) UC patients. Male gender, disease activity, intestinal surgery, NSAID usage and reduced physical activity were significant risk factors. Hospitalization was associated with gallstones and kidney stones. The presence of gallstones increased the risk for kidney stones (OR 4.87, p<0.001).
The diagnosis of CD, intestinal surgery, prolonged NSAID use, disease activity and duration and bowel stenosis were significantly associated with cholecystonephrolithiasis in IBD.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Gallstones/epidemiology, Gallstones/etiology, Hospitalization, Humans, Incidence, Inflammatory Bowel Diseases/complications, Kidney Calculi/epidemiology, Kidney Calculi/etiology, Male, Middle Aged, Prospective Studies, Risk Factors, Switzerland/epidemiology, Time Factors, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
06/11/2017 18:32
Last modification date
20/08/2019 15:28