Insulin resistant states and insulin signaling
Details
Serval ID
serval:BIB_B9EB86696AA1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Insulin resistant states and insulin signaling
Journal
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621 (Print)
Publication state
Published
Issued date
09/2003
Volume
41
Number
9
Pages
1107-19
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Abstract
The incidence of type 2 diabetes mellitus (T2D) and obesity is increasing rapidly worldwide, reaching epidemic proportions. Insulin resistance is a key feature in both conditions and plays an important pathophysiological role. Over the last two decades a central role in the origin of insulin resistance has emerged for defects in the intracellular insulin signaling cascade leading to glucose uptake. Herein, we will 1) review insulin signaling pathways leading to glucose uptake, 2) review mouse models of insulin resistance that demonstrate the pathophysiologic importance of specific defects of these pathways and 3) discuss the molecular basis for insulin resistance in some human disease states known to be associated with insulin resistance. Finally, we will briefly mention some novel treatment targets for T2D stemming from this knowledge.
Keywords
1-Phosphatidylinositol 3-Kinase/metabolism
Animals
Cytoskeletal Proteins/metabolism
Diabetes Mellitus, Type 2/genetics/therapy
Disease Models, Animal
Female
Glucose/metabolism
Humans
Insulin/*physiology
*Insulin Resistance/genetics
Mice
Mice, Transgenic
Phosphoproteins/metabolism
Polycystic Ovary Syndrome/complications
*Signal Transduction
Pubmed
Web of science
Create date
25/01/2008 15:06
Last modification date
20/08/2019 16:27