Insulin resistant states and insulin signaling

Details

Serval ID
serval:BIB_B9EB86696AA1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Insulin resistant states and insulin signaling
Journal
Clinical Chemistry and Laboratory Medicine
Author(s)
Vollenweider  P.
ISSN
1434-6621 (Print)
Publication state
Published
Issued date
09/2003
Volume
41
Number
9
Pages
1107-19
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Abstract
The incidence of type 2 diabetes mellitus (T2D) and obesity is increasing rapidly worldwide, reaching epidemic proportions. Insulin resistance is a key feature in both conditions and plays an important pathophysiological role. Over the last two decades a central role in the origin of insulin resistance has emerged for defects in the intracellular insulin signaling cascade leading to glucose uptake. Herein, we will 1) review insulin signaling pathways leading to glucose uptake, 2) review mouse models of insulin resistance that demonstrate the pathophysiologic importance of specific defects of these pathways and 3) discuss the molecular basis for insulin resistance in some human disease states known to be associated with insulin resistance. Finally, we will briefly mention some novel treatment targets for T2D stemming from this knowledge.
Keywords
1-Phosphatidylinositol 3-Kinase/metabolism Animals Cytoskeletal Proteins/metabolism Diabetes Mellitus, Type 2/genetics/therapy Disease Models, Animal Female Glucose/metabolism Humans Insulin/*physiology *Insulin Resistance/genetics Mice Mice, Transgenic Phosphoproteins/metabolism Polycystic Ovary Syndrome/complications *Signal Transduction
Pubmed
Web of science
Create date
25/01/2008 14:06
Last modification date
20/08/2019 15:27
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