Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial.

Details

Serval ID
serval:BIB_B9C5484676E7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial.
Journal
The American journal of clinical nutrition
Author(s)
Berger M.M., Spertini F., Shenkin A., Wardle C., Wiesner L., Schindler C., Chiolero R.L.
ISSN
0002-9165
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
68
Number
2
Pages
365-71
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Infections remain the leading cause of death after major burns. Trace elements are involved in immunity and burn patients suffer acute trace element depletion after injury. In a previous nonrandomized study, trace element supplementation was associated with increased leukocyte counts and shortened hospital stays. This randomized, placebo-controlled trial studied clinical and immune effects of trace element supplements. Twenty patients, aged 40 +/- 16 y (mean +/- SD), burned on 48 +/- 17% of their body surfaces, were studied for 30 d after injury. They consumed either standard trace element intakes plus supplements (40.4 micromol Cu, 2.9 micromol Se, and 406 micromol Zn; group TE) or standard trace element intakes plus placebo (20 micromol Cu, 0.4 micromol Se, and 100 micromol Zn; group C) for 8 d. Demographic data were similar for both groups. Mean plasma copper and zinc concentrations were below normal until days 20 and 15, respectively (NS). Plasma selenium remained normal for group TE but decreased for group C (P < 0.05 on days 1 and 5). Total leukocyte counts tended to be higher in group TE because of higher neutrophil counts. Proliferation to mitogens was depressed compared with healthy control subjects (NS). The number of infections per patient was significantly (P < 0.05) lower in group TE (1.9 +/- 0.9) than in group C (3.1 +/- 1.1) because of fewer pulmonary infections. Early trace element supplementation appears beneficial after major burns; it was associated with a significant decrease in the number of bronchopneumonia infections and with a shorter hospital stay when data were normalized for burn size.
Keywords
Adult, Burns, Dietary Supplements, Double-Blind Method, Female, Humans, Leukocyte Count, Male, Middle Aged, Pneumonia, Trace Elements
Pubmed
Web of science
Create date
25/01/2008 15:19
Last modification date
20/08/2019 15:27
Usage data