Effect of clonidine on ICP and on the hemodynamic responses to nociceptive stimuli in patients with brain tumors

Details

Serval ID
serval:BIB_B96D5FE0B42F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of clonidine on ICP and on the hemodynamic responses to nociceptive stimuli in patients with brain tumors
Journal
Journal of Neurosurgical Anesthesiology
Author(s)
Favre  J. B., Gardaz  J. P., Ravussin  P.
ISSN
0898-4921 (Print)
Publication state
Published
Issued date
07/1995
Volume
7
Number
3
Pages
159-67
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jul
Abstract
The effect of clonidine on intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), heart rate (HR), and drug requirements was studied in 24 patients scheduled for elective cerebral tumor resection (ICP < or = 20 mm Hg). The patients were randomly assigned to one of two groups: Group P (placebo), 12 patients; Group C (clonidine 3 micrograms/kg 10 min before induction), 12 patients. In all patients, anesthesia was induced with a propofol infusion (500 micrograms/kg/min) combined with fentanyl 2 micrograms/kg, lidocaine 1.5 mg/kg, and vecuronium 0.1 mg/kg. Propofol was also used for maintenance. During the preinduction period, clonidine had no effect on ICP or HR, but in clonidine-treated patients, MAP and CPP decreased significantly in comparison to those of the placebo group. During induction, ICP and HR were stable and similar in both groups. MAP and CPP remained significantly lower in Group C. At intubation and Mayfield clamp application, ICP increased in both groups, with similar values at all times. MAP increased in both groups at intubation, Mayfield clamp application, and incision, staying lower, however, in Group C. CPP followed a pattern similar to that of MAP. Propofol requirements up to the 20th min were lower in Group C than in Group P (2.08 +/- 0.83 vs. 3.3 +/- 0.7 mg/kg, p < 0.05). Finally, throughout the study, eight patients in Group C versus two in Group P had a CPP value < 60 mm Hg for > or = 1 min (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adrenergic alpha-Agonists/*pharmacology Adult Aged Anesthesia Brain Neoplasms/*physiopathology/surgery Clonidine/*pharmacology Female Hemodynamic Processes/*drug effects Humans Intracranial Pressure/*drug effects Intubation, Intratracheal Male Middle Aged Pain/*physiopathology Preanesthetic Medication
Pubmed
Web of science
Create date
28/01/2008 10:48
Last modification date
20/08/2019 15:27
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