Treatment of acute pulmonary hypertension with inhaled nitric oxide

Details

Serval ID
serval:BIB_B935D476F769
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of acute pulmonary hypertension with inhaled nitric oxide
Journal
Annals of Thoracic Surgery
Author(s)
Tonz  M., von Segesser  L. K., Schilling  J., Luscher  T. F., Noll  G., Leskosek  B., Turina  M. I.
ISSN
0003-4975
Publication state
Published
Issued date
10/1994
Peer-reviewed
Oui
Volume
58
Number
4
Pages
1031-1035
Notes
Journal Article --- Old month value: Oct
Abstract
We examined the effectiveness of inhaled nitric oxide (NO) as a selective pulmonary vasodilator in acute pulmonary hypertension in an in vivo canine model with fixed cardiac output. In 5 dogs, total right heart bypass was instituted, and pulmonary hypertension was induced by infusion of the thromboxane analogue U-46619. During U-46619 infusion, NO was administered at 10 and 40 ppm for 5 minutes followed by breathing of the oxygen mixture without NO. Pump flow was held constant during the experiment. Infusion of the thromboxane analogue resulted in an increase in pulmonary vascular resistance and systemic vascular resistance from 147 +/- 83 to 740 +/- 126 dyne.s.cm-5 and from 1,720 +/- 113 to 2,407 +/- 232 dyne.s.cm-5, respectively. During inhalation of 10 ppm NO, pulmonary vascular resistance significantly decreased to 613 +/- 55 dyne.s.cm-5 (p < 0.05) and further decreased to 527 +/- 163 dyne.s.cm-5 with 40 ppm NO inhalation (p < 0.05). Systemic vascular resistance did not change during NO treatment (2,300 +/- 70 dyne.s.cm-5 during 40 ppm NO). There was no increase in intrapulmonary shunting or methemoglobin levels during NO inhalation. In this setting, with a constant cardiac output throughout the experiment, NO acted as a selective pulmonary vasodilator without altering systemic vascular resistance. However, induced pulmonary vasoconstriction was only partially reversed by NO inhalation.
Keywords
Acute Disease Administration, Inhalation Animals Dogs Hypertension, Pulmonary/*drug therapy/physiopathology Nitric Oxide/administration & dosage/*pharmacology/therapeutic use Pulmonary Circulation/drug effects Vascular Resistance/drug effects Vasodilator Agents/administration & dosage/*pharmacology/therapeutic use
Pubmed
Web of science
Create date
14/02/2008 14:18
Last modification date
20/08/2019 15:27
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