Site of airway obstruction: effects on the acoustic impedance of excised pig lungs

Details

Serval ID
serval:BIB_B9319F5EE632
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Site of airway obstruction: effects on the acoustic impedance of excised pig lungs
Journal
Journal of Applied Physiology
Author(s)
Feihl  F., Simon  N., Jaeggi  C., Depeursinge  C., Perret  C.
ISSN
8750-7587 (Print)
Publication state
Published
Issued date
04/1988
Volume
64
Number
4
Pages
1387-96
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
We investigated the relationship between the site of airway obstruction and the frequency dependence (FD) of lung acoustic impedance (ZL). The real (RL) and imaginary (XL) parts of ZL were measured by forced random noise in excised left pig lungs, before (base line) and after 1) no airway obstruction (controls, n = 10), 2) insufflation of 1-mm (B1, n = 5) or 2-mm (B2, n = 7) beads, and 3) partial reversible obstruction of lower lobar (LL) and then main-stem (MS) bronchus (n = 4). The beads caused both partial and total obstruction of airways with internal diameters of 2 mm (B1) and 2-6 mm (B2). Compared with base line, a negative FD of RL appeared from 4 to 10 Hz in LL, B1, and B2 obstructions. The FD of XL greater than 20 Hz increased in MS and LL obstruction exclusively and was the ZL feature that most clearly differentiated central from peripheral obstruction. In this experimental model, the anatomic limit distal from which obstruction no longer causes the "central" type of ZL change lies in airways with internal diameters notably greater than 2 mm.
Keywords
Acoustic Impedance Tests Airway Obstruction/*physiopathology *Airway Resistance Animals Disease Models, Animal Lung/*physiology/physiopathology Swine
Pubmed
Web of science
Create date
25/01/2008 9:37
Last modification date
20/08/2019 15:27
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