Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin.

Details

Serval ID
serval:BIB_B9247F5BEEC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin.
Journal
FEBS letters
Author(s)
Roduit R., Thorens B.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Publication state
Published
Issued date
29/09/1997
Peer-reviewed
Oui
Volume
415
Number
2
Pages
179-182
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Here we evaluated the effect of leptin on glucose-induced insulin secretion by normal rat pancreatic islets. We show in perifusion experiments that leptin had no acute effect on the secretory activity of beta-cells. However, following preexposure to leptin a pronounced time- and dose-dependent inhibition of both first and second phases of secretion was observed. Maximum inhibition was obtained at 24 h and with 100 nM leptin. This inhibition did not involve a decrease in cellular insulin content. It was also not observed with islets from fa/fa rats. Leptin thus inhibits insulin secretion by a mechanism which requires long-term preexposure to the hormone and which may involve alteration in beta-cell gene expression.

Keywords
Animals, Glucose/pharmacology, Insulin/secretion, Islets of Langerhans/drug effects, Islets of Langerhans/secretion, Leptin, Male, Proteins/pharmacology, Rats, Rats, Sprague-Dawley, Recombinant Proteins/pharmacology
Pubmed
Web of science
Create date
24/01/2008 13:41
Last modification date
20/08/2019 15:27
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