Reassessing the Role of Diacylglycerols in Insulin Resistance.

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State: Public
Version: Author's accepted manuscript
License: All rights reserved
Serval ID
serval:BIB_B91FD44325E1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Reassessing the Role of Diacylglycerols in Insulin Resistance.
Journal
Trends in endocrinology and metabolism
Author(s)
Jayasinghe S.U., Tankeu A.T., Amati F.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
30
Number
9
Pages
618-635
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of obesity, particularly because it leads to glucose intolerance and type 2 diabetes. Among the mechanisms thought to link IR to obesity is the accumulation, in muscle cells, of different lipid metabolites. Diacylglycerols (DAGs) are subject of particular attention due to reported interactions with the insulin signaling cascade. Given that SM accounts for the majority of insulin-stimulated glucose uptake, this review integrates recent observational and mechanistic works with the sole focus on questioning the role of DAGs in SM IR. Particular attention is given to the subcellular distributions and specific structures of DAGs, highlighting future research directions towards reaching a consensus on the mechanistic role played by DAGs.
Keywords
Animals, Diglycerides/metabolism, Humans, Insulin Resistance/physiology, Lipid Metabolism/physiology, Muscle, Skeletal/metabolism, Muscle, Skeletal/physiology, intramuscular triglycerides, intramyocellular lipids, lipid droplets, lipotoxicity
Pubmed
Web of science
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-149398
Swiss National Science Foundation / Careers / PZ00P3-126339
Swiss National Science Foundation / Projects / 320030_170062
Create date
09/08/2019 14:01
Last modification date
12/08/2020 6:22
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