Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.

Details

Serval ID
serval:BIB_B90BC34FFB9B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.
Journal
Science
Author(s)
Bach E.A., Szabo S.J., Dighe A.S., Ashkenazi A., Aguet M., Murphy K.M., Schreiber R.D.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1995
Volume
270
Number
5239
Pages
1215-1218
Language
english
Abstract
Interferon gamma (IFN-gamma) responsiveness in certain cells depends on the state of cellular differentiation or activation. Here an in vitro developmental system was used to show that IFN-gamma produced during generation of the CD4+ T helper cell type 1 (TH1) subset extinguishes expression of the IFN-gamma receptor beta subunit, resulting in TH1 cells that are unresponsive to IFN-gamma. This beta chain loss also occurred in IFN-gamma-treated TH2 cells and thus represents a specific response of CD4+ T cells to IFN-gamma rather than a TH1-specific differentiation event. These results define a mechanism of cellular desensitization where a cytokine down-regulates expression of a receptor subunit required primarily for signaling and not ligand binding.
Keywords
Animals, Antigens, CD/biosynthesis, Cell Differentiation, Cell Line, Cytokines/biosynthesis, Down-Regulation, Gene Expression, Genes, MHC Class I, Interferon-gamma/pharmacology, Ligands, Mice, Mice, Transgenic, Receptors, Interferon/biosynthesis, Th1 Cells/cytology, Th1 Cells/immunology, Th2 Cells/cytology, Th2 Cells/immunology
Pubmed
Web of science
Create date
28/01/2008 11:36
Last modification date
20/08/2019 15:27
Usage data