Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder.

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State: Public
Version: Final published version
Serval ID
serval:BIB_B9064F322D07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder.
Journal
Acta Psychiatrica Scandinavica
Author(s)
Golmard J.L., Scott J., Etain B., Preisig M., Aubry J.M., Henry C., Jamain S., Azorin J.M., Leboyer M., Bellivier F.
ISSN
1600-0447 (Electronic)
ISSN-L
0001-690X
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
133
Number
3
Pages
205-213
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: It is suggested that age at onset (AAO) of bipolar I disorder (BP-I) is decreasing. We tested for a birth-cohort effect on AAO using admixture analysis.
METHOD: A clinical sample of 3896 BP-I cases was analysed using two approaches: (i) in a subsample with untruncated AAO × birth year distribution (n = 1865), we compared the best-fitting model for the observed AAO in patients born ≤1960 and >1960, (ii) to control for potential confounders, two separate subsamples born ≤1960 and >1960 were matched for age at interview (n = 250), and a further admixture analysis was undertaken.
RESULTS: The two approaches indicated that the proportion of cases in the early AAO category was significantly greater in cases born >1960; manic onsets were also more frequent in the early onset BP-I cases born >1960.
CONCLUSION: The decrease in AAO of BP-I in recent birth-cohorts appears to be associated with an increase in the proportion of cases in the early onset subgroup; not with a decrease in the mean AAO in each putative subgroup. This could indicate temporal changes in exposure to risk factors for mania.
Pubmed
Web of science
Create date
28/08/2015 16:23
Last modification date
20/08/2019 16:27
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