Does a bolus of mannitol initially aggravate intracranial hypertension? A study at various PaCO2 tensions in dogs

Details

Serval ID
serval:BIB_B9026AE870FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Does a bolus of mannitol initially aggravate intracranial hypertension? A study at various PaCO2 tensions in dogs
Journal
British Journal of Anaesthesia
Author(s)
Abou-Madi  M., Trop  D., Abou-Madi  N., Ravussin  P.
ISSN
0007-0912
Publication state
Published
Issued date
05/1987
Peer-reviewed
Oui
Volume
59
Number
5
Pages
630-9
Notes
Journal Article --- Old month value: May
Abstract
In two groups of anaesthetized dogs, with (n = 28) or without (n = 28) induced intracranial hypertension, we compared the effects on intracranial pressure (ICP) of the rapid administration of mannitol 2 g kg-1 i.v. at PaCO2 2.7, 4.0, 5.3, and 6.7 kPa (n = 7). In dogs with no induced intracranial hypertension, ICP increased during the administration of mannitol, reached a peak at 2 min after infusion, and then gradually decreased (P less than 0.05). More marked changes in ICP were observed in response to higher values of PaCO2 (P less than 0.05). In dogs with induced intracranial hypertension, the rapid infusion of mannitol caused an exponential decrease in ICP, without initial increase, which was significantly steeper at higher values of PaCO2 (P less than 0.05). This was followed by a more gradual decrease which achieved pre-balloon inflation values 10 min after infusion. We postulate that the absence of the initial increase in ICP is the result of a concomitant decrease in arterial pressure, a reduction in the volume-pressure response of the brain, the failure of mannitol to dilate further the cerebral arterial vascular bed and a hitherto unnoticed early water-drawing effect. Our study confirmed the safety of rapidly expanding the circulating blood volume with mannitol in circumstances of increased ICP in dogs.
Keywords
Animals Blood Pressure/drug effects Carbon Dioxide/*physiology Dogs Heart Rate/drug effects Intracranial Pressure/*drug effects Mannitol/*pharmacology
Pubmed
Web of science
Create date
17/01/2008 16:20
Last modification date
20/08/2019 15:27
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