Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells.

Details

Serval ID
serval:BIB_B8FE8E74B0CC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Steroid hormone receptor in pleural solitary fibrous tumours and CD34+ progenitor stromal cells.
Journal
Journal of Pathology
Author(s)
Bongiovanni M., Viberti L., Pecchioni C., Papotti M., Thonhofer R., Hans Popper H., Sapino A.
ISSN
0022-3417 (Print)
ISSN-L
0022-3417
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
198
Number
2
Pages
252-257
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Solitary fibrous tumours (SFT), originally described in the pleura, were subsequently recognized in numerous extrapleural sites. This suggests that a common stem cell, present in various organs and tissues, may be at the origin of SFT and that specific factors may be involved in the proliferation of such cells. Recently it has been described that steroid hormone receptors, progesterone receptors in particular, are expressed by extrapleural SFT. In addition, progesterone may participate as growth factor in many CD34(+) stromal neoplasms, which express low levels of the hormone receptors. The present study analysed the expression of androgen (AR), oestrogen (ER) and progesterone (PR) receptors in a series of 32 pleural SFT, 10 mesotheliomas and in reactive tissue of chronic pleuritis. ER and AR were never expressed by SFT or by chronic pleuritis, whereas PR were demonstrated in 2/16 "large" (>8 cm) and in 6/16 "small" (< or =8 cm) pleural SFT (all expressing CD34, bcl-2 and CD99). PR(+) SFT had a significantly higher proliferative activity (p = 0.04) (Ki-67 mean value 6.5%) and lower p27(kip1) (mean value 51.5%) expression than the PR(-) cases (Ki-67 mean value 3.81% and p27(kip1) mean value 57.86%). One of the cases expressing a high level of PR (80%) recurred 1 year after first surgery and the recurrence was PR(+) as well, but with a lower percentage of nuclear receptor expression (12%). In addition, in chronically inflamed subserosal tissue, a subpopulation of CD34(+) endothelial and interstitial dendritic cells was identified, which also expressed PR. These findings suggest that the CD34(+) submesothelial interstitial dendritic cells, activated during reactive processes, may be the stem cells that give rise to SFT, and that progesterone might participate in the growth of SFT through modulation of its specific receptors.
Keywords
Adolescent, Adult, Aged, Antigens, CD34/analysis, Dendritic Cells/metabolism, Dendritic Cells/pathology, Female, Follow-Up Studies, Humans, Immunophenotyping, Male, Middle Aged, Neoplasm Proteins/metabolism, Neoplasms, Fibrous Tissue/immunology, Neoplasms, Fibrous Tissue/metabolism, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Pleural Neoplasms/immunology, Pleural Neoplasms/metabolism, Receptors, Progesterone/metabolism, Stromal Cells/metabolism, Stromal Cells/pathology
Pubmed
Web of science
Create date
05/02/2015 15:02
Last modification date
20/08/2019 15:27
Usage data