The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.

Details

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B8F42ADC229C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade.
Journal
Gynecologic Oncology
Author(s)
Kandalaft L.E., Singh N., Liao J.B., Facciabene A., Berek J.S., Powell D.J., Coukos G.
ISSN
1095-6859 (Electronic)
ISSN-L
0090-8258
Publication state
Published
Issued date
2010
Volume
116
Number
2
Pages
222-233
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
In the past decade we have witnessed important advances in the treatment of gynecological cancers and have recognized their potential immunogenicity. This has opened the door to explore immune therapy not only in HPV-induced cancers but also in ovarian and endometrial cancers. Here we will review the off-target immune effects of select chemotherapy drugs commonly used to treat gynecologic cancers and novel tools that can stimulate both the adaptive and innate immune mechanisms such as novel pleiotropic cytokines, Toll-like receptors, and powerful antibodies that can target inhibitory checkpoints, thereby activating effector cellular immune mechanisms and neutralizing suppressor cells. We will also review how existing drugs can be used for combinatorial tumor therapy.
Keywords
Combined Modality Therapy, Drug Therapy/methods, Female, Genital Neoplasms, Female/drug therapy, Genital Neoplasms, Female/immunology, Humans, Immunotherapy/methods
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 15:27
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