Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?

Details

Serval ID
serval:BIB_B8DE105EED9A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's "magic (nano)bullet" for cancer theranostics?
Journal
Cancer treatment reviews
Author(s)
Datta N.R., Krishnan S., Speiser D.E., Neufeld E., Kuster N., Bodis S., Hofmann H.
ISSN
1532-1967 (Electronic)
ISSN-L
0305-7372
Publication state
Published
Issued date
11/2016
Peer-reviewed
Oui
Volume
50
Pages
217-227
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Effective multimodal cancer management requires the optimal integration of diagnostic and therapeutic modalities. Radiation therapy, chemotherapy and immunotherapy, alone or in combination, are integral parts of various cancer treatment protocols. Hyperthermia at 39-45°C is a potent radiosensitiser and has been shown to improve therapeutic outcomes in various tumours through its synergy with chemotherapy. Gene silencing approaches, using small interfering RNAs and microRNAs, are also being explored in clinical trials in oncology. The rapid developments in multifunctional nanoparticles provide ample opportunities to integrate both diagnostic and therapeutic modalities into a single effective cancer "theranostic" vector. Nanoparticles could extravasate passively into the tumour tissues in preference to the adjacent normal tissues by capitalizing on the enhanced permeability and retention effect. Tumour targeting might be further augmented by conjugating tumour-specific peptides and antibodies onto the surface of these nanoparticles or by activation through electromagnetic radiations, laser or ultrasound. Magnetic nanoparticles can induce hyperthermia in the presence of an alternating magnetic field, thereby multifunctionally with tumour-specific payloads empowering tumour specific radiotheranostics (for both imaging and radiotherapy), chemotherapy drug delivery, immunotherapy and gene silencing therapy. Such a (nano)bullet could realise the "magic bullet" conceived by Paul Ehrlich more than a century ago. This article discusses the various aspects of this "magic (nano)bullet" and the challenges that need to be addressed to usher in this new paradigm in modern cancer diagnostics and therapeutics.

Keywords
Antineoplastic Agents/therapeutic use, Combined Modality Therapy, Drug Delivery Systems, Ferric Compounds/therapeutic use, Humans, Hyperthermia, Induced/methods, Magnetic Fields, Magnetite Nanoparticles/therapeutic use, Magnets, Nanoparticles/therapeutic use, Neoplasms/diagnostic imaging, Neoplasms/therapy, RNAi Therapeutics/methods, Theranostic Nanomedicine
Pubmed
Create date
25/10/2016 16:35
Last modification date
20/08/2019 15:26
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