A harmonized occupational biomonitoring approach.

Details

Serval ID
serval:BIB_B8D176B61581
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A harmonized occupational biomonitoring approach.
Journal
Environment international
Author(s)
Hopf N.B., Rousselle C., Poddalgoda D., Lamkarkach F., Bessems J., Schmid K., Jones K., Takaki K., Casteleyn L., Zare Jeddi M., Bader M., Koller M., Browne P., FitzGerald R., Viegas S., Göen T., Santonen T., Väänänen V., Duca R.C., Pasanen-Kase R.
ISSN
1873-6750 (Electronic)
ISSN-L
0160-4120
Publication state
Published
Issued date
09/2024
Peer-reviewed
Oui
Volume
191
Pages
108990
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Biomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood). Biomonitoring considers all routes and sources of exposure. An occupational biomonitoring guidance document has been elaborated (OECD Occupational Biomonitoring Guidance) within the OECD framework and specifically, the Working Parties on Exposure and Hazard Assessment by scientific experts from 40 institutes and organizations representing 15 countries. The guidance provides practical information for assessing chemical exposures in occupational settings including the three common routes of exposure: inhalation, skin absorption and ingestion due to hand to mouth contact. The elaborated stepwise approach for conducting biomonitoring is tailored for occupational health professionals, scientists, risk assessors, and regulators. It includes methods for selecting appropriate biomarkers, devising sampling strategies, and assessing laboratories for validated analytical methods for the biomarker of interest, and ensuring timely feedback of results. Furthermore, it describes procedures for setting up efficient biomonitoring programs based on the Similar Exposure Group (SEG) approaches. Derived health-based human exposure biomarker assessment values called Occupational Biomonitoring Levels (OBLs) are proposed for use in occupational exposure and risk assessment. It also helps with the interpretation of biomonitoring results routinely collected and procedures for communicating biomonitoring results at individual, collective, and workplace levels. Ethical considerations associated with biomonitoring are also discussed. The ultimate goal of this biomonitoring approach is to promote harmonized application and interpretation of biomarkers as well as evidence-based occupational risk management measures.
Keywords
Humans, Occupational Exposure/analysis, Biological Monitoring/methods, Biomarkers/urine, Risk Assessment/methods, Environmental Monitoring/methods, Biological monitoring, Effect biomarkers, Exposure biomarkers, Risk assessment, Risk management, Toxicokinetics
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2024 15:48
Last modification date
02/10/2024 7:06
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