Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type.

Details

Serval ID
serval:BIB_B8C83E2F2DCF
Type
Article: article from journal or magazin.
Collection
Publications
Title
Clinical and positron emission tomographic studies in the 'extrapyramidal syndrome' of dementia of the Alzheimer type.
Journal
Archives of Neurology
Author(s)
Tyrrell P.J., Sawle G.V., Ibanez V., Bloomfield P.M., Leenders K.L., Frackowiak R.S., Rossor M.N.
ISSN
0003-9942 (Print)
ISSN-L
0003-9942
Publication state
Published
Issued date
1990
Volume
47
Number
12
Pages
1318-1323
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Extrapyramidal signs, particularly rigidity and tremor, have been reported in a proportion of patients with dementia of the Alzheimer type. To test the hypothesis that these extrapyramidal signs are similar clinically and neurochemically to the extrapyramidal signs of Parkinson's disease, a group of 20 patients satisfying clinical criteria for probable Alzheimer's disease were studied and assessed clinically for the presence of rigidity, tremor, and bradykinesia. In those patients with extrapyramidal signs, qualitative differences were observed between the signs in these patients and in subjects with Parkinson's disease. Fifteen of 20 patients underwent fluoro-18-dopa scans, which showed no significant difference in fluoro-18-dopa uptake into the caudate and putamen between normal subjects and the rigid and nonrigid patients with Alzheimer's disease, in contrast to the marked reduction in fluoro-18-dopa uptake into the putamen that is observed in Parkinson's disease. This provides clinical and in vivo neurochemical support for the hypothesis that extranigral factors may be involved in the pathogenesis of rigidity in Alzheimer's disease.
Keywords
Adult, Aged, Alzheimer Disease/complications, Alzheimer Disease/metabolism, Caudate Nucleus/metabolism, Dementia/complications, Dementia/metabolism, Dopamine/metabolism, Homovanillic Acid/metabolism, Humans, Middle Aged, Muscle Rigidity/etiology, Muscle Rigidity/metabolism, Putamen/metabolism, Tomography, Emission-Computed, Tremor/etiology, Tremor/metabolism
Pubmed
Web of science
Create date
06/10/2011 19:59
Last modification date
20/08/2019 15:26
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