Clinical and course characteristics of depression and all-cause mortality: A prospective population-based study.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_B8A927CE8A6D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Clinical and course characteristics of depression and all-cause mortality: A prospective population-based study.
Journal
Journal of Affective Disorders
Author(s)
Lasserre A.M., Marti-Soler H., Strippoli M.P., Vaucher J., Glaus J., Vandeleur C.L., Castelao E., Marques-Vidal P., Waeber G., Vollenweider P., Preisig M.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
189
Pages
17-24
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Given the large heterogeneity of depressive disorders (DD), studying depression characteristics according to clinical manifestations and course is a more promising approach than studying depression as a whole. The purpose of this study was to determine the association between clinical and course characteristics of DD and incident all-cause mortality.
METHODS: CoLaus|PsyCoLaus is a prospective cohort study (mean follow-up duration=5.2 years) including 35-66 year-old randomly selected residents of an urban area in Switzerland. A total of 3668 subjects (mean age 50.9 years, 53.0% women) underwent physical and psychiatric baseline evaluations and had a known vital status at follow-up (98.8% of the baseline sample). Clinical (diagnostic severity, atypical features) and course characteristics (recency, recurrence, duration, onset) of DD according to the DSM-5 were elicited using a semi-structured interview.
RESULTS: Compared to participants who had never experienced DD, participants with current but not remitted DD were more than three times as likely to die (Hazard Ratio: 3.2, 95% CI: 1.1-10.0) after adjustment for socio-demographic and lifestyle characteristics, comorbid anxiety disorders, antidepressant use, and cardiovascular risk factors and diseases. There was no evidence for associations between other depression characteristics and all-cause mortality.
LIMITATIONS: The small proportion of deceased subjects impeded statistical analyses of cause-specific mortality.
CONCLUSIONS: A current but not remitted DD is a strong predictor of all-cause mortality, independently of cardiovascular or lifestyle factors, which suggests that the effect of depression on mortality diminishes after remission and further emphasizes the need to adequately treat current depressive episodes.
Keywords
Adult, Aged, Cardiovascular Diseases/mortality, Cohort Studies, Depression/mortality, Depressive Disorder/mortality, Female, Humans, Male, Mental Health/statistics & numerical data, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, Switzerland/epidemiology
Pubmed
Web of science
Create date
28/09/2015 13:29
Last modification date
27/09/2019 8:57
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