Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines.

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Serval ID
serval:BIB_B897BFDE2F2C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines.
Journal
European Journal of Pediatrics
Author(s)
Cevey-Macherel M., Galetto-Lacour A., Gervaix A., Siegrist C.A., Bille J., Bescher-Ninet B., Kaiser L., Krahenbuhl J.D., Gehri M.
ISSN
1432-1076[electronic]
Publication state
Published
Issued date
2009
Volume
168
Number
12
Pages
1429-1436
Language
english
Abstract
Community-acquired pneumonia (CAP) is a major cause of death in developing countries and of morbidity in developed countries. The objective of the study was to define the causative agents among children hospitalized for CAP defined by WHO guidelines and to correlate etiology with clinical severity and surrogate markers. Investigations included an extensive etiological workup. A potential causative agent was detected in 86% of the 99 enrolled patients, with evidence of bacterial (53%), viral (67%), and mixed (33%) infections. Streptococcus pneumoniae was accounted for in 46% of CAP. Dehydration was the only clinical sign associated with bacterial pneumonia. CRP and PCT were significantly higher in bacterial infections. Increasing the number of diagnostic tests identifies potential causes of CAP in up to 86% of children, indicating a high prevalence of viruses and frequent co-infections. The high proportion of pneumococcal infections re-emphasizes the importance of pneumococcal immunization.
Keywords
Community-acquired pneumonia, Child, WHO guidelines, Pneumococcal infection, Antibiotic, Immunization, Pneumococcal Conjugate Vaccine, Respiratory-Tract Infection, C-Reactive Protein, Real-Time Pcr, Streptococcus-Pneumoniae, Standardized Interpretation, Childhood Pneumonia, Antibody-Responses, Chest Radiographs, Diagnosis
Pubmed
Web of science
Open Access
Yes
Create date
24/11/2009 16:25
Last modification date
01/10/2019 6:19
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