Experience with perindopril in normal volunteers

Details

Serval ID
serval:BIB_B89377F8FCD6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Experience with perindopril in normal volunteers
Journal
Clinical and Experimental Hypertension. Part A, Theory and Practice
Author(s)
Waeber  B., Nussberger  J., Perret  L., Santoni  J. P., Brunner  H. R.
ISSN
1064-1963
0730-0077 (Print)
Publication state
Published
Issued date
1989
Volume
11 Suppl 2
Pages
507-19
Notes
Journal Article
Abstract
The new orally active angiotensin converting enzyme (ACE) inhibitor perindopril was evaluated in normotensive men. Doses of 2 to 16 mg were given once a day for up to one week. Single oral doses of perindopril were found to blunt the pressor response to exogenous angiotensin I in a dose-dependent manner. The drug-induced ACE inhibition, as estimated by the measurement of plasma ACE activity, was maximal 4 to 8 hours post drug intake. ACE activity was still markedly reduced 24 hours after dosing. Plasma levels of angiotensin II and aldosterone decreased significantly, whereas plasma renin activity and blood angiotensin I levels rose during peak ACE inhibition induced by the 4 and 8 mg doses. However, circulating levels of angiotensin II returned to baseline values 24 hours after dosing, both on the first day of treatment and after one week of administration. ACE inhibition with perindopril did not consistently affect blood pressure and heart rate. There was no evidence for drug accumulation during repeated administration. The novel ACE inhibitor was well tolerated and produced no change in routine laboratory tests. The long-acting ACE inhibitor perindopril therefore appears to be effective when given orally in a dose range of 4 to 16 mg.
Keywords
Acetylcholinesterase/blood Administration, Oral Angiotensin I/pharmacology Angiotensin-Converting Enzyme Inhibitors/administration & dosage/*pharmacology Blood Pressure/drug effects Drug Evaluation Drug Tolerance Hemodynamic Processes/drug effects Humans Indoles/administration & dosage/*pharmacology Male Perindopril Renin-Angiotensin System/drug effects
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 15:26
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