Reprogramming G protein coupled receptor structure and function.
Details
Serval ID
serval:BIB_B8903B55516B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Reprogramming G protein coupled receptor structure and function.
Journal
Current opinion in structural biology
ISSN
1879-033X (Electronic)
ISSN-L
0959-440X
Publication state
Published
Issued date
08/2018
Peer-reviewed
Oui
Volume
51
Pages
187-194
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The prominence of G protein-coupled receptors (GPCRs) in human physiology and disease has resulted in their intense study in various fields of research ranging from neuroscience to structural biology. With over 800 members in the human genome and their involvement in a myriad of diseases, GPCRs are the single largest family of drug targets, and an ever-present interest exists in further drug discovery and structural characterization efforts. However, low GPCR expression and stability outside the natural lipid environments have challenged these efforts. In vivo functional studies of GPCR signaling are complicated not only by the need for specific spatiotemporal activation, but also by downstream effector promiscuity. In this review, we summarize the present and emerging GPCR engineering methods that have been employed to overcome the challenges involved in receptor characterization, and to better understand the functional role of these receptors.
Pubmed
Web of science
Create date
24/12/2018 11:02
Last modification date
20/08/2019 15:26