Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila.

Details

Serval ID
serval:BIB_B887D7D0FC78
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila.
Journal
International journal of molecular sciences
Author(s)
Talmat-Amar Y., Arribat Y., Parmentier M.L.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
06/03/2018
Peer-reviewed
Oui
Volume
19
Number
3
Pages
1
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Structural microtubule associated protein Tau is found in high amount in axons and is involved in several neurodegenerative diseases. Although many studies have highlighted the toxicity of an excess of Tau in neurons, the in vivo understanding of the endogenous role of Tau in axon morphology and physiology is poor. Indeed, knock-out mice display no strong cytoskeleton or axonal transport phenotype, probably because of some important functional redundancy with other microtubule-associated proteins (MAPs). Here, we took advantage of the model organism <i>Drosophila</i> , which genome contains only one homologue of the Tau/MAP2/MAP4 family to decipher (endogenous) Tau functions. We found that Tau depletion leads to a decrease in microtubule number and microtubule density within axons, while Tau excess leads to the opposite phenotypes. Analysis of vesicular transport in <i>tau</i> mutants showed altered mobility of vesicles, but no change in the total amount of putatively mobile vesicles, whereas both aspects were affected when Tau was overexpressed. In conclusion, we show that loss of Tau in <i>tau</i> mutants not only leads to a decrease in axonal microtubule density, but also impairs axonal vesicular transport, albeit to a lesser extent compared to the effects of an excess of Tau.
Keywords
Alzheimer’s disease, axonal transport, microtubule, tauopathy
Pubmed
Web of science
Open Access
Yes
Create date
09/07/2018 16:23
Last modification date
21/08/2019 5:37
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