Sudden unexpected death in epilepsy: current knowledge and future directions

Details

Serval ID
serval:BIB_B87B758A2D18
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Sudden unexpected death in epilepsy: current knowledge and future directions
Journal
Lancet Neurol
Author(s)
Tomson T., Nashef L., Ryvlin P.
ISSN
1474-4422 (Print)
ISSN-L
1474-4422
Publication state
Published
Issued date
11/2008
Volume
7
Number
11
Pages
1021-31
Language
english
Notes
Tomson, Torbjorn
Nashef, Lina
Ryvlin, Philippe
eng
Review
England
Lancet Neurol. 2008 Nov;7(11):1021-31. doi: 10.1016/S1474-4422(08)70202-3. Epub 2008 Sep 19.
Abstract
Although largely neglected in earlier literature, sudden unexpected death in epilepsy (SUDEP) is the most important epilepsy-related mode of death, and is the leading cause of death in people with chronic uncontrolled epilepsy. Research during the past two to three decades has shown that incidence varies substantially depending on the epilepsy population studied, ranging from 0.09 per 1000 patient-years in newly diagnosed patients to 9 per 1000 patient-years in candidates for epilepsy surgery. Risk profiles have been delineated in case-control studies. These and other studies indicate that SUDEP mainly occurs in the context of a generalised tonic-clonic seizure. However, it remains unclear why a seizure becomes fatal in a person that might have had many similar seizures in the past. Here, we review SUDEP rates, risk factors, triggers, and proposed mechanisms, and critically assess potential preventive strategies. Gaps in knowledge are discussed and ways forward are suggested.
Keywords
Animals, Brain/physiopathology, Cohort Studies, Comorbidity, Death, Sudden/*epidemiology/prevention & control, Disease Models, Animal, Epidemiologic Studies, Epilepsy/*mortality/physiopathology, Humans, Incidence, Risk Factors, Seizures/mortality/physiopathology
Pubmed
Create date
29/11/2018 12:37
Last modification date
20/08/2019 15:26
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