Imagerie cérébrale et motricité dans la maladie de Parkinson

Details

Serval ID
serval:BIB_B872766989E5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Imagerie cérébrale et motricité dans la maladie de Parkinson
Journal
Bulletin de l'Académie Nationale de Médecine
Author(s)
Frackowiak R.S., Dowsey-Limousin P., Jahanshahi M., Hariz M.
ISSN
0001-4079 (Print)
ISSN-L
0001-4079
Publication state
Published
Issued date
2003
Volume
187
Number
2
Pages
295-304
Language
french
Notes
Brain imaging and motor function in Parkinson's disease
Abstract
Numerous abnormalities of motor function have been identified in Parkinson's disease and functional imaging methods have given us a better understanding of underlying mechanisms. An underactivity of some frontal areas, in particular the supplementary motor area and the dorsolateral-prefrontal cortex, has been found in several studies. The activity of these areas increases when motor function improves following administration of dopaminergic drugs or functional neurosurgery. The dysfunction of the basal ganglia-thalamo-cortical loops in Parkinson's disease and in particular the excess of inhibition of the thalamo-cortical pathway by the internal pallidum is likely to be involved in the abnormal activity of the cortical areas. An excess of activation has been demonstrated in other areas and is probably compensatory.
Keywords
Basal Ganglia/drug effects, Basal Ganglia/physiopathology, Brain/pathology, Brain/radionuclide imaging, Brain Mapping, Dopamine Agonists/pharmacology, Dopamine Agonists/therapeutic use, Humans, Motor Activity/physiology, Parkinson Disease/drug therapy, Parkinson Disease/physiopathology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
11/09/2011 18:35
Last modification date
20/08/2019 15:26
Usage data