Association diclofenac-dexamethasone dans le traitement de l'inflammation postopératoire: étude prospective en double-insu [Diclofenac-dexamethasone combination in treatment of postoperative inflammation: prospective double-blind study].

Details

Serval ID
serval:BIB_B86C550DD669
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association diclofenac-dexamethasone dans le traitement de l'inflammation postopératoire: étude prospective en double-insu [Diclofenac-dexamethasone combination in treatment of postoperative inflammation: prospective double-blind study].
Journal
Klinische Monatsblätter für Augenheilkunde
Author(s)
Othenin-Girard P., Borruat X., Bovey E., Pittet N., Herbort C.P.
ISSN
0023-2165 (Print)
ISSN-L
0023-2165
Publication state
Published
Issued date
1992
Peer-reviewed
Oui
Volume
200
Number
5
Pages
362-366
Language
french
Notes
Publication types: Clinical Trial ; English Abstract ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
In a prospective randomized double masked study including 40 patients we evaluated the anti-inflammatory effect of a combination of dexamethasone acetate 0.1% + diclofenac 0.1% drops compared to dexamethasone acetate 0.1% + placebo drops, after ECCE + posterior chamber lens implantation. Anterior chamber (AC) flare and cells were measured with the laser flare-cell meter Kowa FC-1000. The group receiving the dexamethasone-diclofenac combination showed a more rapid decrease of AC flare which was significant at days D3 (P less than 0.003) and D12 (p less than 0.028). The reduction of AC cells was comparable in both groups, showing however a strong tendency toward a lower cell count in the group receiving diclofenac at days D12 and D30 (p less than 0.08). Tolerance of diclofenac was good and comparable to the placebo.
Keywords
Aged, Anterior Chamber/drug effects, Dexamethasone/administration & dosage, Diclofenac/administration & dosage, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Inflammation/drug therapy, Lenses, Intraocular, Male, Middle Aged, Postoperative Complications/drug therapy
Pubmed
Web of science
Create date
28/01/2008 12:40
Last modification date
20/08/2019 15:26
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