Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.

Details

Serval ID
serval:BIB_B860FE645B4E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.
Journal
Journal of lipid research
Author(s)
Yu Y., Wyszynski D.F., Waterworth D.M., Wilton S.D., Barter P.J., Kesäniemi Y.A., Mahley R.W., McPherson R., Waeber G., Bersot T.P., Ma Q., Sharma S.S., Montgomery D.S., Middleton L.T., Sundseth S.S., Mooser V., Grundy S.M., Farrer L.A.
ISSN
0022-2275
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
46
Number
10
Pages
2202-13
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
We conducted a genome-wide scan using variance components linkage analysis to localize quantitative-trait loci (QTLs) influencing triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol, and total cholesterol (TC) levels in 3,071 subjects from 459 families with atherogenic dyslipidemia. The most significant evidence for linkage to TG levels was found in a subset of Turkish families at 11q22 [logarithm of the odds ratio (LOD)=3.34] and at 17q12 (LOD=3.44). We performed sequential oligogenic linkage analysis to examine whether multiple QTLs jointly influence TG levels in the Turkish families. These analyses revealed loci at 20q13 that showed strong epistatic effects with 11q22 (conditional LOD=3.15) and at 7q36 that showed strong epistatic effects with 17q12 (conditional LOD=3.21). We also found linkage on the 8p21 region for TG in the entire group of families (LOD=3.08). For HDL-C levels, evidence of linkage was identified on chromosome 15 in the Turkish families (LOD=3.05) and on chromosome 5 in the entire group of families (LOD=2.83). Linkage to QTLs for TC was found at 8p23 in the entire group of families (LOD=4.05) and at 5q13 in a subset of Turkish and Mediterranean families (LOD=3.72). These QTLs provide important clues for the further investigation of genes responsible for these complex lipid phenotypes. These data also indicate that a large proportion of the variance of TG levels in the Turkish population is explained by the interaction of multiple genetic loci.
Keywords
Adult, Atherosclerosis, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Chromosomes, Human, Dyslipidemias, Female, Genome, Human, Humans, Lod Score, Male, Middle Aged, Quantitative Trait Loci, Triglycerides
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:10
Last modification date
20/08/2019 15:26
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