Perivascular epithelioid cell tumor (PEComa) of the uterus: A case report

Details

Serval ID
serval:BIB_B85B8DD7F2A0
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Perivascular epithelioid cell tumor (PEComa) of the uterus: A case report
Title of the conference
81. Jahrestagung der Schweizerischen Gesellschaft für Pathologie
Author(s)
Caseiro Silverio P., Achtari C., Stravodimou A., Fiche M.
Address
Basel, Switzerland, 12.-14. November 2015
ISBN
0172-8113
ISSN-L
0172-8113
Publication state
Published
Issued date
2015
Volume
36
Series
Der Pathologe
Pages
625
Language
english
Abstract
Background. Perivascular epithelioid cell tumors (PEComas) are a rare family of mesenchymal tumors arising in a wide array of anatomic locations and characterized by coexpression of melanocytic and muscle markers. The uterus accounts for around one-fourth of the overall PEComa cases reported in the literature. Methods. We report a case of PEComa of the uterus with multiple malignancy features. Results. A uterine mass suspect for leiomyosarcoma was found in a 53-year-old woman with post-menopausal bleeding. Total hysterectomy and bilateral adnexectomy was performed. The tumor measured 7 cm in diameter, was unique, well-circumscribed, nodular, and whiteyellow without haemorrhage or necrosis. Microscopically, two populations of cells could be seen: small fusiform cells growing in fascicles resembling a smooth muscle tumor, and large epithelioid cells with abundant pale vacuolated cytoplasm growing in a diffuse pattern. Cytologic atypias were marked and mitoses numerous and often atypical in the second component. The tumor infiltrated into the myometrium with lymphovascular invasion. Immunostains showed positivity for MelanA, HMB45, smooth muscle actin, CD10, TFE3 and cathepsin K. Conclusions. This PEComa case presents several of the recently precised criteria for malignancy (Schoolmeester JK et al. Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: Clinicopathologic and immunohistochemical characterization of 16 cases. Am J Surg Pathol 2014; 38:176-188).
Create date
18/11/2015 16:57
Last modification date
20/08/2019 15:26
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