Vitamin D Status and the Host Resistance to Infections: What It Is Currently (Not) Understood.

Details

Serval ID
serval:BIB_B85A7B6B5A9A
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Vitamin D Status and the Host Resistance to Infections: What It Is Currently (Not) Understood.
Journal
Clinical therapeutics
Author(s)
Lang P.O., Aspinall R.
ISSN
1879-114X (Electronic)
ISSN-L
0149-2918
Publication state
Published
Issued date
05/2017
Peer-reviewed
Oui
Volume
39
Number
5
Pages
930-945
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Vitamin D is increasingly thought to play a role in regulating immunity. This comprehensive review updates the current understanding regarding ways in which we believe that vitamin D regulates responsiveness of the immune system and how serum status modulates the host defense against pathogens.
The literature was searched by using PubMed and Scopus with the following key words: vitamin D, immunity, innate and adaptive immunity, infectious disease, and vaccine response.
Vitamin D deficiency remains a major public health concern worldwide. The overall body of evidence confirms that vitamin D plays an important role in modulating the immune response to infections. Epidemiologic studies suggest a clear association between vitamin D deficiency and susceptibility to various pathogens. However, translation of vitamin D use into the clinic as a means of controlling infections is fraught with methodologic and epidemiologic challenges. The recent discovery of alternative activation pathways, different active forms of vitamin D, and possible interaction with non-vitamin D receptors provide further complications to an already complex interaction between vitamin D and the immune system. Moreover, it has become apparent that the individual responsiveness to supplementation is more dynamic than presumed from the static assessment of 25-hydroxy vitamin D status. Furthermore, the epigenetic response at the level of the individual to environmental changes and lifestyle or health conditions provides greater variation than those resulting from vitamin D receptor polymorphisms.
To understand the future of vitamin D with respect to clinical applications in the prevention and better control of infectious diseases, it is necessary to determine all aspects of vitamin D metabolism, as well as the mechanisms by which active forms interact with the immune system globally. For the most part, we are unable to identify tissue-specific applications of supplementation except for those subjects at high risk of osteomalacia and osteoporosis.

Keywords
Animals, Communicable Diseases/blood, Communicable Diseases/drug therapy, Communicable Diseases/immunology, Dietary Supplements, Disease Resistance/immunology, Humans, Immunologic Factors/blood, Immunologic Factors/immunology, Immunologic Factors/therapeutic use, Vaccines/therapeutic use, Vitamin D/blood, Vitamin D/immunology, Vitamin D/therapeutic use, Vitamins/blood, Vitamins/immunology, Vitamins/therapeutic use, immune response, immunity, infections, vaccine, vitamin D, vitamin D status, vitamin D supplementation
Pubmed
Web of science
Create date
09/05/2017 17:33
Last modification date
20/08/2019 15:26
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